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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Modified method for evaluation of micronuclei in lymphocytes using hybridization of pancentrometric fluorescently labelled probes
 Rössner ml., Pavel ; Rössnerová, Andrea
This methodology is based on the simultaneous fluorescent staining of both whole chromosomes and their centromere using pancentrometric probes. Thanks to this, it is possible to evaluate the frequencies of micronuclei with / without centromeres, ie to determine the differences between structural and numerical aberrations. The aim of the methodology was to create an innovative procedure for evaluating the genotoxic effects of nanoparticles, chemicals, including drugs or radiation on the DNA of living organisms.
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